QSAR and Docking Based Semi-Synthesis and In Vivo Evaluation of Artemisinin Derivatives for Antimalarial Activity
Dharmendra Kumar Yadav, Sangeeta Dhawan, Akanksha Chauhan, Tabish Qidwai, Pooja Sharma, Rajendra Singh Bhakuni, Om Prakash Dhawan and Feroz Khan
Affiliation: Metabolic & Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, P.O.-CIMAP, Kukrail Picnic Spot Road, Lucknow-226015 (U.P.) India.
To screen the active antimalarial novel artemisinin derivatives, a QSAR modeling approach was used. QSAR
model showed high correlation (r2= 0.83 and rCV2= 0.81) and indicated that Connectivity Index (order 1, standard), Connectivity
Index (order 2, standard), Dipole Moment (debye), Dipole Vector X (debye) and LUMO Energy (eV) well correlate
with activity. High binding likeness on antimalarial target plasmepsin was detected through molecular docking. Active
artemisinin derivatives showed significant activity and indicated compliance with standard parameters of oral
bioavailability and ADMET. The active artemisinin derivatives namely, β-Artecyclopropylmether HMCP (A3), β–
Artepipernoylether (PIP-1) (A4) and 9-(β-Dihydroartemisinoxy)methyl anthracene (A5) were semi-synthesized and characterized
based on its 1H and 13C NMR spectroscopic data and later activity tested in vivo on mice infected with multidrug
resistant strain of P. yoelii nigeriensis. Predicted results were successfully validated by in vivo experiments.
Keywords: Artemisinin, ADMET, docking, malaria, plasmepsins, p. yoelii nigeriensis, QSAR.
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