Medicinal Chemistry Discoveries among 1,3,5-Triazines: Recent Advances (2000-2013) as Antimicrobial, Anti-TB, Anti-HIV and Antimalarials

Author(s): Rahul V. Patel, Young-Soo Keum, Se Won Park.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 14 , Issue 9 , 2014

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Abstract:

The chemistry and an extensive spectrum of biological activities of s-triazines have been examined since several decades and this heterocyclic core has received emerging consensus. This article aims to summarize recent advances (2000-2013) made towards the discovery of antimicrobial, antituberculosis, anti-HIV and antimalarial agents holding 1,3,5-triazine ring as a nucleus with the substitution of several types of nucleophiles. Molecular patterns associated with particular potency have been identified targeting several Gram-positive and Gram-negative bacteria and some fungal species, mycobacterium tuberculosis H37Rv, HIV type I and HIV type II, particularly, HIV-1I IIB and HIV- 1ROD strains as well as a variety of P. falciparum malarial strains as chloroquine-resistant K1, chloroquine-susceptible NF54, chloroquine-sensitive 3D7, P. falciparum (D6 clone), P. falciparum (W2 clone), cycloguanil-resistant FCR-3, chloroquine sensitive RKL2. The report will be of considerable interest to gain useful information for the furtherance of drug discovery with extended 1,3,5-triazine designs.

Keywords: Anti-TB activity, anti-HIV activity, antimalarial activity, antimicrobial activity, drug discovery, s-triazine.

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Article Details

VOLUME: 14
ISSUE: 9
Year: 2014
Page: [768 - 789]
Pages: 22
DOI: 10.2174/1389557514666140622205904
Price: $58

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