Recent Androgen Receptor Antagonists in Prostate Cancer

Author(s): Xufang Lu, Kang Dun, Yang Wang, Yong Yang, Qidong You, Zhiyu Li.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 14 , Issue 8 , 2014

Abstract:

Androgen receptor has been shown to promote prostate cell growth and carcinogenesis of prostate cancer by up-regulating its target genes. Testosterone and dihydrotestosterone are two major hormones which bind to and activate androgen receptor. Targeting both the androgen receptor and the enzymes catalyzing the biosynthesis of testosterone and dihydrotestosterone has been shown to be clinically beneficial in the treatment of prostate cancer. Prostate cancer can become castration-resistant after long term treatment with chemo drugs, so efforts in finding compounds with improved efficiency to castration-resistant prostate cancer are urgently needed. In this review we summarized the studies on recent progress in the development of small molecular AR antagonists for the treatment of prostate cancer.

Keywords: Androgen receptor, castration-resistant prostate cancer, prostate cancer.

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Article Details

VOLUME: 14
ISSUE: 8
Year: 2014
Page: [655 - 663]
Pages: 9
DOI: 10.2174/1389557514666140622203207
Price: $58

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