One-pot, Solvent-free Cascade Michael-reductive Cyclization Reaction for the Synthesis of Ethyl 3, 5-disubstituted-1H-pyrrole-2-carboxylates under Microwave Irradiation
Rajni Khajuria and Kamal K. Kapoor
An efficient, one-pot, solvent-free synthesis of ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylate is achieved by a reaction of 1,3-disubstituted propen-2-one and ethylnitroacetate, in presence of diethylamine (Et2NH) and triethylphosphite (P(OEt)3) under microwave (MW) irradiation via cascade Michael-reductive cyclization. The mechanistic outcome of the reaction has also been described. This protocol establishes an easy access to disubstituted-1H-pyrrole-2-carboxylates in one pot.
Cascade, 1, 3-disubstituted propen-2-ones, diethylamine, ethyl 3, 5-disubstituted-1H-pyrrole-2-carboxylates, ethylnitroacetate,
one-pot, Michael-reductive cyclization, MW irradiation, triethylphosphite, solvent-free
Department of Chemistry, University of Jammu, Jammu-180 006, India.