One-pot, Solvent-free Cascade Michael-reductive Cyclization Reaction for the Synthesis of Ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylates Under Microwave Irradiation
Rajni Khajuria and Kamal K. Kapoor
Affiliation: Department of Chemistry, University of Jammu, Jammu-180 006, India.
Keywords: 1, 3-disubstituted propen-2-ones, cascade, diethylamine, ethyl 3, 5-disubstituted-1H-pyrrole-2-carboxylates, ethylnitroacetate,
Michael-reductive cyclization, MW irradiation, one-pot, solvent-free, triethylphosphite.
An efficient, one-pot, solvent-free synthesis of ethyl 3,5-disubstituted-1H-pyrrole-2-carboxylate is achieved by
a reaction of 1,3-disubstituted propen-2-one and ethylnitroacetate, in presence of diethylamine (Et2NH) and triethylphosphite
(P(OEt)3) under microwave (MW) irradiation via cascade Michael-reductive cyclization. The mechanistic outcome
of the reaction has also been described. This protocol establishes an easy access to disubstituted-1H-pyrrole-2-
carboxylates in one pot.
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