Combination of Phytochemicals as Adjuvants for Cancer Therapy
John W.S. Ho and Matt W.M. Cheung
Affiliation: Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P.R. China.
Newer treatments of advanced human cancer are based on combination of cancer drugs that have different
mechanism of actions yet the combination strategy may potentiate the anti-cancer effects and cytotoxicity. Recent studies
suggest that cancer growth can be inhibited more effectively by combination of phytochemicals that affect different pathways.
The apoptotic activity can be modulated by intrinsic and extrinsic molecules. The combination of anti-tumor phytochemicals
can be more effective in modulating different signaling pathways associated with tumor cell growth which is
the common target for anti-tumor action. Combinations of cytotoxic anti-tumor agents and inhibitors from phytochemicals
are believed to act together producing inhibitory mechanisms on cancer growth. This combination strategy shows promise
on cancer therapy. However, the combination of phytochemicals in cancer therapy needs to be further investigated to develop
a better treatment strategy. Recent patents on anti-tumor phytochemicals are reviewed in this article.
Keywords: Anti-proliferation, apoptosis, cancer, cell growth, drug combination, natural products, phytochemicals.
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