Suppression of Inflammatory and Allergic Responses by Pharmacologically Potent Fungus Ganoderma lucidum
Neha Bhardwaj, Priya Katyal and Anil K. Sharma
Affiliation: Department of Biotechnology, M. M. University, Mullana (Ambala), Haryana, India-133207.
Keywords: Anti-allergic, anti-inflammatory, formulations, Ganoderma lucidum, immune-modulating, inflammation.
Acute inflammation is the result of a complex signal transduction pathway that protects and heals our body and
is necessary for our good health and normal wellbeing. Whereas, chronic inflammation can be correlated well with the onset
of a plethora of autoimmune disorders; rheumatoid arthritis, systemic lupus and polymyalgia, rheumatic and other diseases
like asthma, inflammatory bowel diseases, cardiovascular disorders, ulcerative colitis and Crohn’s disease. Also, it
has been reported to be associated with the onset of various cancers. An effective anti-inflammatory drug should be able
to inhibit the development of chronic inflammation without interfering in normal homeostasis. A number of herbal drugs
have been identified in the past that can target inflammatory cytokines. Among these, Ganoderma lucidum: a powerful
medicinal mushroom has been found to possess immune-modulating and immune-potentiating capabilities and has been
characterized as a wonder herb. This review mainly focuses on the molecular mechanism of anti-inflammatory and antiallergic
action of this mushroom and also sheds light on various patent studies related to its pharmacological action.
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