Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Synthetic Glycosylated Natural Products Have Satisfactory Activities

Author(s): Gangliang Huang and Xinya Mei

Affiliation: College of Chemistry, Chongqing Normal University, Chongqing 401331, China.

Keywords: Activities, glycosylated natural products, recent development, total synthesis.

Graphical Abstract:


Many natural products contain sugar residues, which are essential components for great medicinal importance. The sugar moieties can improve water-solubility of natural products and decrease their toxicity. At the same time, the glycosidic residues are crucial for the activities of natural products. Much effort has been expended over the past decades in developing novel and efficient methodologies to synthesize the glycosylated natural products. This review highlights recent developments in the synthesis of glycosylated natural products. The structure-activity relationships of some of these glycosylated natural products, together with the structure characteristics of their interaction with the biological targets, are also involved.

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Article Details

Page: [780 - 784]
Pages: 5
DOI: 10.2174/1389450115666140617153348