Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System

Author(s): Ting Kang, Xiaoling Gao, Jun Chen.

Journal Name: Current Pharmaceutical Biotechnology

Volume 15 , Issue 3 , 2014

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Abstract:

The existence of blood-brain barrier (BBB) represents the most formidable challenge for drug delivery to the central nervous system (CNS). Modern breakthrough in biology offers multiple choices for overcoming this barrier but yields modest outcomes for clinical application due to various problems such as safety concerns, insufficient delivery efficiency and poor penetration. Cell penetrating peptides (CPPs) possessing powerful transmembrane capacity have been shown to be effective transport vectors for bioactive molecules and an attractive alternative to traditional active targeting approaches. However, the non-specificity of CPPs has hindered them from targeting a desired site of action. Promisingly, design of novel CPP-mediated nanoparticulate delivery systems with specific targeting property may extricate CPPs from the dilemma. In this review, both the traditional and novel applications of CPPs-based strategies for CNS drug delivery will be discussed.

Keywords: Blood-brain barrier, cell penetrating peptides, central nervous system, drug delivery.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2014
Page: [220 - 230]
Pages: 11
DOI: 10.2174/1389201015666140617094952
Price: $58

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