Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs

Author(s): Jiao Tan, Heesun Cheong, Yoon Shin Park, Hangun Kim, Meng Zhang, Cheol Moon, Yongzhuo Huang.

Journal Name: Current Pharmaceutical Biotechnology

Volume 15 , Issue 3 , 2014

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Abstract:

Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.

Keywords: Biomacromolecules, cell-penetrating peptide, intranasal delivery, non-invasive delivery, percutaneous delivery, topical administration.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2014
Page: [231 - 239]
Pages: 9
DOI: 10.2174/1389201015666140617094320
Price: $58

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