Cell Penetrating Peptides and the Mechanisms for Intracellular Entry
Young S. Choi and Allan E. David
Affiliation: Department of Chemical Engineering, 212 Ross Hall, Auburn University, Auburn, AL 36849, USA.
Keywords: Cell penetrating peptide, cellular uptake, drug delivery, lipid bilayer, endocytosis.
A major thrust in the biomedical and pharmaceutical industries is to develop diagnostic and therapeutic tools
that have significantly improved selectivity and specificity compared to the current state-of-the-art. This has driven much
of the effort to look at molecules and materials that are significantly larger than the traditional small molecule agents. Due
to size restrictions, however, many of these materials are unable to penetrate the cell membrane and gain access to the intracellular
components on which they exert their action. The relatively recent discovery of cell penetrating peptides (CPP)
provides a powerful tool that has enabled the intracellular delivery of these materials. While a variety of proteins, DNA,
polymers and even nanoparticles have been successfully delivered into cells, there still remains some debate as to the
mechanism of entry utilized by the CPPs. In this review, we provide a brief outline of the different potential mechanisms
for cellular uptake of CPPs.
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