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Current Pharmaceutical Biotechnology
ISSN (Print): 1389-2010
ISSN (Online): 1873-4316
Epub Full Text Article
DOI: 10.2174/1389201015666140617093331      Price:  $95









Cell Penetrating Peptides and the Mechanisms for Intracellular Entry

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Author(s): Young Suk Choi and Allan E David
Abstract:
A major thrust in the biomedical and pharmaceutical industries is to develop diagnostic and therapeutic tools that have significantly improved selectivity and specificity compared to the current state-of-the-art. This, however, has driven much of the effort to look at molecules and materials that are significantly larger than the traditional small molecule drugs. Due to size restrictions, many of these materials are unable to penetrate the cell membrane and gain access to the intracellular components on which they exert their action. The relatively recent discovery of cell penetrating peptides (CPP) has now provided a powerful tool that has enabled the intracellular delivery of these materials. While a variety of proteins, DNA, polymers and even nanoparticles have been successfully delivered into cells, there still remains some debate as to the mechanism of entry utilized by the CPPs. In this review, we briefly outline the different potential mechanisms for cellular uptake of CPPs
Keywords:
Cell penetrating peptide, cellular uptake, drug delivery, lipid bilayer, endocytosis
Affiliation:
Department of Chemical Engineering 212 Ross Hall, Auburn University Auburn, AL 36849