Recent Patents on Anti-Infective Drug Discovery

Dieter Kabelitz  
Institute of Immunology
Universitätsklinikum Schleswig-Holstein
Campus Kiel


Recent Advances in the Development of Anti-Infective Prophylactic and/or Therapeutic Agents Based on Toll-Like Receptor (TLRs)

Author(s): Elena C. Junquera, Lourdes Mateos-Hernández, Jose de la Fuente and Jose M.P. de la Lastra

Affiliation: Instituto de Investigación en Recursos Cinegéticos, IREC (UCLM-CSIC-JCCLM), Ronda Toledo s/n, 13071 Ciudad Real, Spain.


Toll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses. Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like receptors to develop anti-infective (prophylactic and/or therapeutic) agents.

Keywords: Agonist, antagonist, anti-infective agents, immune therapy, innate immunity, toll-like receptors, vaccine.

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Article Details

Page: [14 - 24]
Pages: 11
DOI: 10.2174/1574891X09666140616164918