Abstract
Toll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses. Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like receptors to develop anti-infective (prophylactic and/or therapeutic) agents.
Keywords: Agonist, antagonist, anti-infective agents, immune therapy, innate immunity, toll-like receptors, vaccine.
Recent Patents on Anti-Infective Drug Discovery
Title:Recent Advances in the Development of Anti-Infective Prophylactic and/or Therapeutic Agents Based on Toll-Like Receptor (TLRs)
Volume: 9 Issue: 1
Author(s): Elena C. Junquera, Lourdes Mateos-Hernández, Jose de la Fuente and Jose M.P. de la Lastra
Affiliation:
Keywords: Agonist, antagonist, anti-infective agents, immune therapy, innate immunity, toll-like receptors, vaccine.
Abstract: Toll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses. Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like receptors to develop anti-infective (prophylactic and/or therapeutic) agents.
Export Options
About this article
Cite this article as:
Junquera C. Elena, Mateos-Hernández Lourdes, Fuente de la Jose and Lastra M.P. de la Jose, Recent Advances in the Development of Anti-Infective Prophylactic and/or Therapeutic Agents Based on Toll-Like Receptor (TLRs), Recent Patents on Anti-Infective Drug Discovery 2014; 9 (1) . https://dx.doi.org/10.2174/1574891X09666140616164918
DOI https://dx.doi.org/10.2174/1574891X09666140616164918 |
Print ISSN 1574-891X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4071 |
Related Articles
-
Prostacyclin, Atherothrombosis and Diabetes Mellitus: Physiologic and Clinical Considerations
Current Molecular Medicine Non-Viral Gene Delivery Methods
Current Pharmaceutical Biotechnology Recent Updates on Current and Upcoming Biomarkers for Cardiovascular Diseases
Current Pharmaceutical Design New Insight into the Mechanisms of <i>Ginkgo Biloba</i> Extract in Vascular Aging Prevention
Current Vascular Pharmacology Endothelin-1 and Human Platelets
Current Vascular Pharmacology Therapeutic Potential of Plant Extracts and Phytochemicals Against Brain Ischemia-Reperfusion Injury: A Review
The Natural Products Journal New Glycoside Esters from the Aerial Parts of Artemisia absinthium Linn.
The Natural Products Journal PACAP and Its Receptors Exert Pleiotropic Effects in The Nervous System by Activating Multiple Signaling Pathways
Current Protein & Peptide Science Vitamin D/VDR in Acute Kidney Injury: A Potential Therapeutic Target
Current Medicinal Chemistry Editorial (Hot Topic: Neuroprotection and Neuroregeneration in Ischemic Stroke: Emerging Treatment Strategies and Potential Molecular Targets)
Current Drug Targets Molecular Chaperone Disorders: Defective Hsp60 in Neurodegeneration
Current Topics in Medicinal Chemistry Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity
Current Pharmaceutical Design Relaxin as a Cardiovascular Hormone: Physiology, Pathophysiology and Therapeutic Promises
Cardiovascular & Hematological Agents in Medicinal Chemistry Peroxynitrite-Driven Mechanisms in Diabetes and Insulin Resistance – the Latest Advances
Current Medicinal Chemistry Therapeutic Potential of N-Acetylcysteine for Wound Healing, Acute Bronchiolitis, and Congenital Heart Defects
Current Drug Metabolism Proinflammatory Cytokines and Chemokines in Neonatal Brain Damage
Current Pediatric Reviews Stem Cells Treatment for Wilson Disease
Current Stem Cell Research & Therapy Specific Targeting of Engineered Nanoparticles to Activated Macrophages
Current Nanoscience Peptide Metabolism and the Control of Body Fluid Homeostasis
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Synergistic Effect of Inhibitors of MMPs and ROS-dependent Modifications of Contractile Proteins on Protection Hearts Subjected to Oxidative Stress
Current Pharmaceutical Design