Recent Advances in the Development of Anti-Infective Prophylactic and/or Therapeutic Agents Based on Toll-Like Receptor (TLRs)
Elena C. Junquera, Lourdes Mateos-Hernández, Jose de la Fuente and Jose M.P. de la Lastra
Affiliation: Instituto de Investigación en Recursos Cinegéticos, IREC (UCLM-CSIC-JCCLM), Ronda Toledo s/n, 13071 Ciudad Real, Spain.
Keywords: Agonist, antagonist, anti-infective agents, immune therapy, innate immunity, toll-like receptors, vaccine.
Toll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms
ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses.
Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune
disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like
receptors to develop anti-infective (prophylactic and/or therapeutic) agents.
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