Inflammation & Allergy-Drug Targets

(Formerly Current Drug Targets - Inflammation & Allergy)

Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448
Germany

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Neuromodulatory and Anti-Inflammatory Ingredient for Sensitive Skin: In Vitro Assessment

Author(s): Adilson Costa, Samara Eberlin, Anelise J. Polettini, Andreia F. da Costa Pereira, Caroline S. Pereira, Nayara M. Cortes Ferreira, Eleonora Dolis and Liliana B. Oliveira Torloni

Affiliation: KOLderma Clinical Trials Institute, Campinas/SP, Brazil.

Keywords: Envelope proteins, neurogenic inflammation, neuropeptide, POMC, sensitive skin, TRPV1.

Abstract:

The manifestation of sensitive skin occurs as a consequence of increased permeability of the Stratum corneum, besides the involvement of neuro-immune-endocrine system. In this study, we evaluated the effects of an active ingredient SensC on the production of neuropeptides substance P (SP), enkephalin and β-endorphin; eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4); histamine, transient receptor potential vanilloid subfamily member 1 (TRPV1), and envelope proteins filaggrin and involucrin, using an in vitro model of human cell culture. Our results demonstrated that treatment of keratinocyte cultures with SensC prevented the increase of all evaluated inflammatory mediators induced by interleukin-1 alpha (IL-1α). As the same way, SensC provides decrease in the synthesis of TRPV1. Regarding the synthesis of envelope proteins, SensC promoted increases for filaggrin and involucrin levels, when compared to control group. Considering the absence of appropriate treatment, the availability of ingredients, such as SensC, with antiinflammatory and protective barrier properties can be a significant tool for preventing neurosensorial symptoms associated with sensitive skin.

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Article Details

VOLUME: 13
ISSUE: 3
Page: [191 - 198]
Pages: 8
DOI: 10.2174/1871528113666140616112708