Neuromodulatory and Anti-Inflammatory Ingredient for Sensitive Skin: In Vitro Assessment
Adilson Costa, Samara Eberlin, Anelise J. Polettini, Andreia F. da Costa Pereira, Caroline S. Pereira, Nayara M. Cortes Ferreira, Eleonora Dolis and Liliana B. Oliveira Torloni
Affiliation: KOLderma Clinical Trials Institute, Campinas/SP, Brazil.
The manifestation of sensitive skin occurs as a consequence of increased permeability of the Stratum corneum,
besides the involvement of neuro-immune-endocrine system. In this study, we evaluated the effects of an active ingredient
SensC on the production of neuropeptides substance P (SP), enkephalin and β-endorphin; eicosanoids prostaglandin E2
(PGE2) and leukotriene B4 (LTB4); histamine, transient receptor potential vanilloid subfamily member 1 (TRPV1), and
envelope proteins filaggrin and involucrin, using an in vitro model of human cell culture. Our results demonstrated that
treatment of keratinocyte cultures with SensC prevented the increase of all evaluated inflammatory mediators induced by
interleukin-1 alpha (IL-1α). As the same way, SensC provides decrease in the synthesis of TRPV1. Regarding the
synthesis of envelope proteins, SensC promoted increases for filaggrin and involucrin levels, when compared to control
group. Considering the absence of appropriate treatment, the availability of ingredients, such as SensC, with antiinflammatory
and protective barrier properties can be a significant tool for preventing neurosensorial symptoms
associated with sensitive skin.
Keywords: Envelope proteins, neurogenic inflammation, neuropeptide, POMC, sensitive skin, TRPV1.
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