Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

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Synthesis of New and Known Dicoumarols in Aqueous Media: A Green and Convenient Procedure Promoted by Titanium(IV) Oxide Nanoparticles

Author(s): Saeed Khodabakhshi, Mozhgan Shahamirian and Mojtaba Baghernejad

Affiliation: Young Researchers and Elite Club, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.

Keywords: Titanium(IV) oxide nanoparticles, chemoselectivity, 3, 3'-(2-aryl-2-oxoethylidene)bis[4-hydroxycoumarin]s, catalysts, arylglyoxal.

Graphical Abstract:


Abstract:

A simple and green method is reported for the completely chemoselective synthesis of some new dicoumarol derivatives {3,3'-(2-aryl-2-oxoethylidene)bis[4-hydroxycoumarin]s} from the reaction of 4-hydroxycoumarin with arylglyoxals in a molar ratio of 2:1 respectively. The reactions efficiently promoted by titanium(IV) oxide nanoparticles as a heterogeneous catalyst via an on water process. Catalyst loading is very low and it shows recyclability.

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Article Details

VOLUME: 11
ISSUE: 8
Page: [596 - 600]
Pages: 5
DOI: 10.2174/157017861108140613162852