Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Synthesis and Evaluation of Anti-inflammatory and Analgesic Activities of New 1,2,4-triazole Derivatives

Author(s): Fatemeh Ahmadi, Mohsen Rezayan Ghayahbashi, Mohammad Sharifzadeh, Eskandar Alipoiur, Seyed Nasser Ostad, Mohsen Vosooghi, Hamid Reza khademi, Mohsen Amini.

Graphical Abstract:


Abstract:

In this study, the synthesis, anti-inflammatory and analgesic activities of eight new 5-thioalkyl-1,3-diaryl-1,2,4- triazole derivatives were reported. For the anti-inflammatory study, the carrageenan-induced rat paw edema model was used. The test compounds in 50 mg/kg and 100 mg/kg were injected as IP and paw edema was determined. The results showed that some of the compounds have good activity compared to the references drug, indomethacin. For analgesic activity, the test compounds were studied using the in Tail-flick test model in 50 and 100 mg/kg as IP injections. Their analgesic activities were determined after 30 min via latency time assay. Statistical analysis showed that all test compounds have antinociceptive activity in the range of 24% -47% as compared to the control with a dose of 50 mg/kg. However, all tested compounds have analgesic activity lower than the standard drug, morphine.

Keywords: Anti-inflammatory activity, analgesic activity, 1, 2, 4-tiazole derivatives, diarylheterocyclic compounds.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2015
Page: [69 - 76]
Pages: 8
DOI: 10.2174/1573406410666140613154507
Price: $58