Synthesis and Evaluation of Anti-inflammatory and Analgesic Activities of New 1,2,4-triazole Derivatives
Mohsen Rezayan Ghayahbashi,
Seyed Nasser Ostad,
Hamid Reza khademi,
In this study, the synthesis, anti-inflammatory and analgesic activities of eight new 5-thioalkyl-1,3-diaryl-1,2,4-
triazole derivatives were reported. For the anti-inflammatory study, the carrageenan-induced rat paw edema model was
used. The test compounds in 50 mg/kg and 100 mg/kg were injected as IP and paw edema was determined. The results
showed that some of the compounds have good activity compared to the references drug, indomethacin. For analgesic activity,
the test compounds were studied using the in Tail-flick test model in 50 and 100 mg/kg as IP injections. Their analgesic
activities were determined after 30 min via latency time assay. Statistical analysis showed that all test compounds
have antinociceptive activity in the range of 24% -47% as compared to the control with a dose of 50 mg/kg. However, all
tested compounds have analgesic activity lower than the standard drug, morphine.
Keywords: Anti-inflammatory activity, analgesic activity, 1, 2, 4-tiazole derivatives, diarylheterocyclic compounds.
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