Vitamin D and miRNAs in Cancer
Donald L. Trump,
Candace S. Johnson.
Vitamin D is a steroid hormone that regulates mineral homeostasis, bone metabolism and many other physiological
processes. The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D (1,25D3), has broad spectrum antitumor
activities and potentiates the effects of a number of chemotherapeutic agents. 1,25D3 exerts its anti-tumor effects
mainly through genomic mechanisms involving the regulation of gene transcription through vitamin D response elements
(VDREs). More recently, miRNAs have been shown to be regulated by 1,25D3. miRNAs are short non-coding RNAs that
post-transcriptionally modulate the expression of a wide range of genes. Therefore, they have important regulatory roles in
the development and progression of many diseases including cancer. This review focuses on the regulation of miRNA expression
by 1,25D3 in cancer model systems and the contribution of the regulated miRNAs to the anti-tumor effect of
1,25D3. In addition, the impact of miRNAs on 1,25D3 signaling is discussed.
Keywords: calcitriol, cancer, microRNA, vitamin D.
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