Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Intracellular Delivery of Potential Therapeutic Genes: Prospects in Cancer Gene Therapy

Author(s): Athirah Bakhtiar, Mustak Sayyad, Rozita Rosli, Atsushi Maruyama, Ezharul H. Chowdhury.

Abstract:

Conventional therapies for malignant cancer such as chemotherapy and radiotherapy are associated with poor survival rates owing to the development of cellular resistance to cancer drugs and the lack of targetability, resulting in unwanted adverse effects on healthy cells and necessitating the lowering of therapeutic dose with consequential lower efficacy of the treatment. Gene therapy employing different types of viral and non-viral carriers to transport gene(s) of interest and facilitating production of the desirable therapeutic protein(s) has tremendous prospects in cancer treatments due to the high-level of specificity in therapeutic action of the expressed protein(s) with diminished off-target effects, although cancer cell-specific delivery of transgene(s) still poses some challenges to be addressed. Depending on the potential therapeutic target genes, cancer gene therapy could be categorized into tumor suppressor gene replacement therapy, immune gene therapy and enzyme- or prodrug-based therapy. This review would shed light on the current progress of delivery of potentially therapeutic genes into various cancer cells in vitro and animal models utilizing a variety of viral and non-viral vectors.

Keywords: Gene therapy, cancer, nanoparticles, liposomes, polymer, adenovirus, p53, p21, thymidine kinase, TRAIL, cytokine, angiotensin, interleukin, interferon.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2014
Page: [247 - 257]
Pages: 11
DOI: 10.2174/1566523214666140612152730
Price: $58