Non-invasive stimulation of the human brain to improve depressive symptoms is increasingly finding its way in
clinical settings as a viable form of somatic treatment. Following successful modulation of neural excitability with
subsequent antidepressant effects, neural polarization by administrating weak direct currents to the scalp has gained
renewed interest. A new wave of basic and clinical studies seems to underscore the potential therapeutic value of direct
current stimulation in the treatment of depression. Issues concerning the lack of mechanistic insights into the workings of
modifying brain function through neural polarization and how this process translates to its antidepressant properties calls
for additional research. The range of its clinical applicability has yet to be established.
Keywords: Depressive disorder, non-invasive brain stimulation, transcranial direct current stimulation, treatment.
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