CNS & Neurological Disorders - Drug Targets

(Formerly Current Drug Targets - CNS & Neurological Disorders)

Stephen D. Skaper  
Department of Pharmaceutical and Pharmacological Sciences
University of Padova
Padova
Italy

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Current Directions in Non-Invasive Low Intensity Electric Brain Stimulation for Depressive Disorder

Author(s): Dennis J.L.G. Schutter, Alexander T. Sack.

Abstract:

Non-invasive stimulation of the human brain to improve depressive symptoms is increasingly finding its way in clinical settings as a viable form of somatic treatment. Following successful modulation of neural excitability with subsequent antidepressant effects, neural polarization by administrating weak direct currents to the scalp has gained renewed interest. A new wave of basic and clinical studies seems to underscore the potential therapeutic value of direct current stimulation in the treatment of depression. Issues concerning the lack of mechanistic insights into the workings of modifying brain function through neural polarization and how this process translates to its antidepressant properties calls for additional research. The range of its clinical applicability has yet to be established.

Keywords: Depressive disorder, non-invasive brain stimulation, transcranial direct current stimulation, treatment.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2014
Page: [945 - 952]
Pages: 8
DOI: 10.2174/1871527313666140612115123
Price: $58