Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life,
productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great
psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to
review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving
animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test
(FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant
effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors
CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.
Keywords: Anxiety, anxiolytic-like, cannabis sativa, cannabidiol, CBD, major depression.
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