Facile Synthesis of Novel N4-Substituted 2-(Trifluoromethyl)-tetrahydrobenzothieno[ 2,3-d]pyrimidine Derivatives
Fasong Wang, Hui Gao, Ping Yang, Yan Wang and Xinjian Song
Affiliation: Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Hubei Minzu University, Xueyuan Road, Enshi, Hubei 445000, P.R. China.
A series of novel N4-substituted 2-(trifluoromethyl)-tetrahydrobenzothieno[2,3-d]pyrimidine derivatives were
synthesized by a facile three-step procedure that presented such advantages as easily accessible starting materials, mild reaction
conditions, simple protocol and good overall yields. The structures of the title compounds were confirmed by IR,
1H NMR, 13C NMR, EI-MS, elemental analysis, and single-crystal X-ray diffraction.
Keywords: Facile synthesis, crystal structure, Gewald reaction, thieno[2, 3-d]pyrimidines, fluorinated compounds.
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