Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

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Facile Synthesis of Novel N4-Substituted 2-(Trifluoromethyl)-tetrahydrobenzothieno[ 2,3-d]pyrimidine Derivatives

Author(s): Fasong Wang, Hui Gao, Ping Yang, Yan Wang and Xinjian Song

Affiliation: Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Hubei Minzu University, Xueyuan Road, Enshi, Hubei 445000, P.R. China.

Keywords: Facile synthesis, crystal structure, Gewald reaction, thieno[2, 3-d]pyrimidines, fluorinated compounds.

Graphical Abstract:


Abstract:

A series of novel N4-substituted 2-(trifluoromethyl)-tetrahydrobenzothieno[2,3-d]pyrimidine derivatives were synthesized by a facile three-step procedure that presented such advantages as easily accessible starting materials, mild reaction conditions, simple protocol and good overall yields. The structures of the title compounds were confirmed by IR, 1H NMR, 13C NMR, EI-MS, elemental analysis, and single-crystal X-ray diffraction.

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Article Details

VOLUME: 11
ISSUE: 9
Page: [700 - 705]
Pages: 6
DOI: 10.2174/1570178611666140609225422