Binaphthyl Based Molecules for Asymmetric Organocatalytic Aldol Reactions: Recent Developments from a Successful Record
Ana R. Almeida, Angela C.B. Neves, Artur R. Abreu, Mario J.F. Calvete and Mariette M. Pereira
Affiliation: Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.
The careful selection of a suitable chiral backbone is vital for the preparation of any modern ligand for asymmetric
catalysis, where binaphthyl based ligands are considered paradigmatic and systematically used in a diversity of
asymmetric catalysed reactions, with emphasis for organocatalysis. Due to the vastness of possible organocatalytic applications,
this review article is mainly focused on the asymmetric aldol and vinylogous aldol reactions organocatalysed by
binaphthyl-based molecules. Special attention is given to catalytic results, particularly on enantio- and diastereoselectivity
obtained by the use of the above binaphthyl chiral inductors.
Keywords: Aldol, binaphthyl derivatives, organocatalysis, C-C bond, Asymmetric catalysis, BINOL, BINAM, NOBIN.
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