Abstract
Topological Indices (TIs) are numerical parameters useful to carry out Quantitative Structure-Property Relationships (QSPR) analysis and predict the effect of perturbations in many types of Complex Networks. This work, focuses on a very powerful class of TIs called Galvez charge transfer indices. First, we review the classic concept and some applications of these indices. Next, we review the Galvez-Markov TIs of order k (GMk), a recent generalization to these TIs introduced by us. We also reviewed some previous examples of calculation of GMk values for different classes of networks, including metabolic networks. Here, we also demonstrated that Galvez- Markov TIs are useful to predict perturbations and the transferability of biochemical patterns forms metabolic networks of species to others. We report a linear QSPR-Perturbation theory model that predicts more than 300,000 perturbations in metabolic networks with 85 – 99% of good classification in training and validation series.
Keywords: Complex networks, QSAR, topological indices, metabolic networks, markov chains.
Current Drug Metabolism
Title:Galvez-Markov Network Transferability Indices: Review of Classic Theory and New Model for Perturbations in Metabolic Reactions
Volume: 15 Issue: 5
Author(s): Jorge Vergara-Galicia, Francisco J. Prado-Prado and Humberto Gonzalez-Diaz
Affiliation:
Keywords: Complex networks, QSAR, topological indices, metabolic networks, markov chains.
Abstract: Topological Indices (TIs) are numerical parameters useful to carry out Quantitative Structure-Property Relationships (QSPR) analysis and predict the effect of perturbations in many types of Complex Networks. This work, focuses on a very powerful class of TIs called Galvez charge transfer indices. First, we review the classic concept and some applications of these indices. Next, we review the Galvez-Markov TIs of order k (GMk), a recent generalization to these TIs introduced by us. We also reviewed some previous examples of calculation of GMk values for different classes of networks, including metabolic networks. Here, we also demonstrated that Galvez- Markov TIs are useful to predict perturbations and the transferability of biochemical patterns forms metabolic networks of species to others. We report a linear QSPR-Perturbation theory model that predicts more than 300,000 perturbations in metabolic networks with 85 – 99% of good classification in training and validation series.
Export Options
About this article
Cite this article as:
Vergara-Galicia Jorge, Prado-Prado J. Francisco and Gonzalez-Diaz Humberto, Galvez-Markov Network Transferability Indices: Review of Classic Theory and New Model for Perturbations in Metabolic Reactions, Current Drug Metabolism 2014; 15 (5) . https://dx.doi.org/10.2174/1389200215666140605125827
DOI https://dx.doi.org/10.2174/1389200215666140605125827 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Tissue Distribution and Metabolism of Micro- and Nanoparticles and Medical Implants
With the continuous advancement of modern science and engineering, numerous functional materials and active molecules have been developed and utilized in various industrial, medical, and food applications. Many of these can enter the body, either actively or passively, and have significant and intricate impacts on human health. For example, biomaterials ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
MicroRNAs and Cancer Therapy – From Bystanders to Major Players
Current Medicinal Chemistry Synthesis of Aza-BODIPY Boron Difluoride PDT Agents to Promote Apoptosis in HeLa Cells
Letters in Organic Chemistry Extracellular Vesicles as Novel Delivery Tools for Cancer Treatment
Current Cancer Drug Targets The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target
Current Cancer Drug Targets Extrahepatic Targets and Cellular Reactivity of Drug Metabolites
Current Medicinal Chemistry Overactive Bladder - Current Treatment Modalities
Current Women`s Health Reviews Anesthetic Cardioprotection in Clinical Practice From Proof-of-Concept to Clinical Applications
Current Pharmaceutical Design Photodynamic Therapy For Non-Melanoma Skin Cancers
Current Cancer Therapy Reviews Synthesis of 9-O-3-(1-piperazinyl/morpholinyl/piperidinyl)pentyl-berberines as Potential Antioxidant and Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry TRP Channels and Pain
Current Pharmaceutical Design Prodrugs in Photodynamic Anticancer Therapy
Current Pharmaceutical Design Three-Dimensional Tissue Models for Drug Discovery and Toxicology
Recent Patents on Biotechnology Experimental Therapy for Lung Cancer: Umbilical Cord-Derived Mesenchymal Stem Cell-Mediated Interleukin-24 Delivery
Current Cancer Drug Targets Association of Viruses in the Development of Cardiovascular Diseases
Current Pharmaceutical Design Antimicrobial Agents Deriving from Indigenous Plants
Recent Patents on Food, Nutrition & Agriculture Understanding the Molecular Properties and Metabolism of Top Prescribed Drugs
Current Topics in Medicinal Chemistry Targeted Tumor Therapies at a Glance
Current Drug Targets Strategies for the Assessment of Metabolic Profiles of Steroid Hormones in View of Diagnostics and Drug Monitoring: Analytical Problems and Challenges
Current Drug Metabolism Soluble Epoxide Hydrolase Inhibitors and their Potential for Treatment of Multiple Pathologic Conditions
Current Medicinal Chemistry Nanoparticle Albumin - Bound (NAB) Technology is a Promising Method for Anti-Cancer Drug Delivery
Recent Patents on Anti-Cancer Drug Discovery