Endocrine, Metabolic & Immune Disorders-Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Emilio Jirillo  
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico


Obesity and Oxidative Stress: Potential Roles of Melatonin as Antioxidant and Metabolic Regulator

Author(s): Dominique Bonnefont-Rousselot

Affiliation: Service de Biochimie Metabolique, Groupe hospitalier Pitie-Salpetriere (Assistance Publique – Hopitaux de Paris), 47-83 boulevard de l'Hopital, 75651 Paris Cedex 13, France.

Keywords: Antioxidant, insulin resistance, melatonin, metabolic syndrome, obesity.


Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems. Several sources of ROS can be identified in obesity (e.g., mitochondrial respiratory chain, or NADPH oxidase) and could contribute to the pathogenesis of obesity. Indeed, these conditions favour the development of insulin resistance and metabolic syndrome through deregulation of adipokines and pro-inflammatory cytokines, so that it could be of interest to associate antioxidant therapeutic strategies with strategies of weight loss. Among antioxidants, melatonin holds a special place, on the one hand for its antioxidant and anti-inflammatory properties, and on the other hand for its role as a metabolic regulator. As melatonin modulates several processes involved in obesity and its related metabolic alterations, it could have a therapeutic interest in the treatment of obesity.

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Article Details

Page: [159 - 168]
Pages: 10
DOI: 10.2174/1871530314666140604151452