Autophagy and Heart Disease: Implications for Cardiac Ischemia- Reperfusion Damage

Author(s): S. Ghavami, S. Gupta, E. Ambrose, M. Hnatowich, D.H. Freed, I.M.C. Dixon.

Journal Name:Current Molecular Medicine

Volume 14 , Issue 5 , 2014

Abstract:

Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of adaptive processes that are invoked with the changes that occur within the parenchyma and stroma. Autophagy is implicated in cellular housekeeping duties and maintenance of the integrity of the intracellular milieu by removal of protein aggregates and damaged organelles, whereas under pathophysiological conditions, the chronic up-regulation of autophagy may lead to significant disturbance of homeostatic conditions. Nonetheless, the role of autophagy in heart disease in the context of cardiac ischemia-reperfusion injury is currently unclear. This review will focus upon the role of autophagy as it pertains to ischemiareperfusion damage in the heart.

Keywords: Autophagy, heart, heart disease, ischemia-reperfusion, mitophagy.

Rights & PermissionsPrintExport

Article Details

VOLUME: 14
ISSUE: 5
Year: 2014
Page: [616 - 629]
Pages: 14
DOI: 10.2174/1566524014666140603101520
Price: $58

Article Metrics

PDF: 34
HTML: 0
EPUB: 0
PRC: 0