Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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DNA Binding Mode of Transition Metal Complexes, A Relationship to Tumor Cell Toxicity

Author(s): M. Ashfaq, T. Najam, S.S.A. Shah, M.M. Ahmad, S. Shaheen, R. Tabassum, G. Rivera.

Abstract:

Transition metal-based compounds constitute a distinct class of chemotherapeutics extensively used in the clinic as antitumor and antiviral agents. However, drug resistance and side effects of established antitumor metallodrugs such as cisplatin [cis-diamminedichloroplatinum(II)] and its analogues, carboplatin and oxaliplatin, have limited their clinical utility. These limitations have prompted a search for more effective and less toxic metal-based antitumor agents. The unique properties of metal ions, such as redox transfer/electron shuttling, and versatile coordination geometries arising from various oxidation states, result in metal ions and complexes that have potential medicinal applications that could be complementary to organic compounds and which are widely sought in drug discovery efforts. This review summarizes the results that show that transition metal complexes exhibit antitumor effects that differ from cisplatin or its analogues.

Keywords: Copper complexes, DNA binding, iron complexes, mechanism of action, platinum complexes, tumor cell.

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Article Details

VOLUME: 21
ISSUE: 26
Year: 2014
Page: [3081 - 3094]
Pages: 14
DOI: 10.2174/0929867321666140601201803
Price: $58