Glycerol Mediated Strecker Reaction: Catalyst-free Protocol for the Synthesis of α-Amino Nitriles

Title:Glycerol Mediated Strecker Reaction: Catalyst-free Protocol for the Synthesis of α-Amino Nitriles

Volume: 11 Issue: 9

Author(s): Ramesh S. Ghogare, K. Rajeshwari and A. Venkat Narsaiah

Affiliation:

Keywords: Strecker reaction, glycerol, aldehyde, amine, TMS-CN, aminonitrile.

Abstract: Environmental friendly multicomponent protocol for the preparation of α-amino nitriles has been developed. In this methodology, glycerol was demonstrated as an efficient and alternative solvent for organic synthesis. After the reaction, glycerol was recovered and reused for further reactions. All the reactions were carried out at room temperature without using catalyst and the products were characterized by their spectroscopy analysis.

Cite this article as:

Ghogare S. Ramesh, Rajeshwari K. and Narsaiah Venkat A., Glycerol Mediated Strecker Reaction: Catalyst-free Protocol for the Synthesis of α-Amino Nitriles, Letters in Organic Chemistry 2014; 11 (9) . https://dx.doi.org/10.2174/1570178611666140530221934