Glycerol Mediated Strecker Reaction: Catalyst-free Protocol for the Synthesis of α-Amino Nitriles

Author(s): Ramesh S. Ghogare, K. Rajeshwari, A. Venkat Narsaiah.

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 9 , 2014

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Abstract:

Environmental friendly multicomponent protocol for the preparation of α-amino nitriles has been developed. In this methodology, glycerol was demonstrated as an efficient and alternative solvent for organic synthesis. After the reaction, glycerol was recovered and reused for further reactions. All the reactions were carried out at room temperature without using catalyst and the products were characterized by their spectroscopy analysis.

Keywords: Strecker reaction, glycerol, aldehyde, amine, TMS-CN, aminonitrile.

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Article Details

VOLUME: 11
ISSUE: 9
Year: 2014
Page: [688 - 692]
Pages: 5
DOI: 10.2174/1570178611666140530221934
Price: $58

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