Floating pulsatile is combined approach designed according to circadian rhythm to deliver the drug at right
time, in right quantity and at right site as per pathophysiological need of disease with prolong gastric residence and lag
phase followed by burst release. As the migraine follows circadian rhythm in which headache is more painful at the awakening
time, the dosage form should be given during night time to release drug when pain get worsen. Present work deals
with formulation and optimization of floating pulsatile tablet of sumatriptan succinate. Core tablet containing crospovidone
as superdisintegrant (10%) showed burst release. Lag time was maintained using swellable polymer as polyoxN12K
and xanthum gum. 32 experimental design was carried out. Developed formulations were evaluated for physical characteristics,
in vitro and in vivo study. Optimized batch F2 with concentration of polyox N12K (73.43%) and xanthum gum
(26.56%) of total polymer weight showed floating lag time 15±2 sec, drug content 99.58±0.2 %, hardness 6±0.2 Kg/cm2
and drug release 99.54±2% with pulsatile manner followed lag period of 7±0.1h. In vivo x-ray study confirms prolong
gastric residence of system. Programmable pulsatile release has been achieved by formulation F2 which meet demand of
chronotherapeutic objective of migraine.
Keywords: Circadian, Floating, Migraine, Optimization, Pulsatile, Tablet.
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