The Assessment and Characterisation of Drug Plasma Protein Binding in the Body Using QSAR
Snezana Agatonovic-Kustrin, David W. Morton and Pauzi A. Yusof
Affiliation: School of Pharmacy and Applied Science, La Trobe Institute of Molecular Sciences, La Trobe University, PO Box 199, Bendigo, 3552, Australia.
Most drugs are carried from the site of absorption to their intended site of action (target site) by the
bloodstream, either dissolved in the serum or bound to plasma proteins. Binding to plasma proteins influences (i.e. limits
or favours), drug distribution through the body. Usually it is the unbound drug concentration that determines its
pharmacological and toxicological properties. Our ability to design suitable drug candidates depends on our ability to
understand the molecular characteristics of drug-protein binding and ideally be able to predict the extent of binding
in vivo. Here we review the different approaches that have been used to model and predict the binding of drugs and drug
like molecules to plasma proteins in the body.
Keywords: Binding, Descriptor, Human serum albumin, Plasma protein, Quantitative structural activity relationship.
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