α-(-)-bisabolol Reduces Pro-inflammatory Cytokine Production and Ameliorates Skin Inflammation
Anil K. Maurya, Monika Singh, Vijaya Dubey, Suchita Srivastava, Suaib Luqman and Dnyaneshwar U. Bawankule
Affiliation: Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, India.
α-(-)-bisabolol is a natural monocyclic sesquiterpene present in the essential oil has generated considerable interest
in the chemical and pharmaceutical industries and currently in use in various formulations, mainly in cosmetics.
This study was undertaken to evaluate its therapeutic profile against skin inflammation using in-vitro, in-vivo and in-silico
assays. Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory
cytokines (TNF-α and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was
significantly inhibited by α-(-)-bisabolol. TPA-induced ear thickness, ear weight and lipid peroxidation and histopathological
damage in the ear tissue were also significantly inhibited by topical application of α-(-)-bisabolol in a dose dependent
manner. In-vitro and in-vivo toxicity profiles indicate that it is safe for topical application on skin. Molecular
docking study also revealed its strong binding affinity to the active site of the pro-inflammatory proteins. These findings
suggested that α-(-)-bisabolol may be a useful therapeutic candidate for the treatment of skin inflammation.
Keywords: α-(-)-bisabolol, anti-inflammatory, macrophage, 12-O-tetradecanoylphorbol-13-acetate, mice, LPS.
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