A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer
Garima Sharma, Pradeep Dua and Subhash Mohan Agarwal
Affiliation: Bioinformatics Division, Institute of Cytology and Preventive Oncology (ICMR) I-7, Sector-39, Noida-201301, India.
MicroRNAs(miRNAs) have become the center of interest in oncology. In recent years, various studies have
demonstrated that miRNAs regulate gene expression by influencing important regulatory genes and thus are responsible
for causing cervical cancer. Cervical cancer being the third most diagnosed cancer among the females worldwide, is the
fourth leading cause of cancer related mortality. Prophylactic human papillomavirus (HPV) vaccines and new HPV
screening tests, combined with traditional Pap test screening have greatly reduced cervical cancer. Yet, thousands of
women continue to be diagnosed with and die of this preventable disease annually. This has necessitated the scientists to
ponder over ways of evolving new methods and chalk out novel treatment protocols/strategies. As miRNA deregulation
plays a key role in malignant transformation of cervical cancer along with its targets that can be exploited for both prognostic
and therapeutic strategies, we have collected and reviewed the role of miRNA in cervical cancer. A systematic
search was performed using PubMed for articles that report aberrant expression of miRNA in cervical cancer. The present
review provides comprehensive information for 246 differentially expressed miRNAs gathered from 51 published articles
that have been implicated in cervical cancer progression. Of these, more than 40 miRNAs have been reported in the literature
in several instances signifying their role in the regulation of cancer. We also identified 40 experimentally validated
targets, studied the cause of miRNAs dysregulation along with its mechanism and role in different stages of cervical cancer.
We also identified and analysed miRNA clusters and their expression pattern in cervical cancer. This review is expected
to further enhance our understanding in this field and serve as a valuable reference resource.
Keywords: miRNA, Cervical cancer, miRNA targets, miRNA cluster, Cervical intraepithelial neoplasia.
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