Alpha-1 Adrenergic Antagonists Induced Severe Rhinitis in Patients with Benign Prostatic Hyperplasia

Author(s): Eduardo Shahar, Laila Nassar, Eynat Kedem, Gammal Hassoun.

Journal Name: Current Drug Safety

Volume 9 , Issue 2 , 2014

Abstract:

The standard gold care medications for benign prostatic hyperplasia (BPH) are the alpha-1-adrenergic antagonists, they are an effective medications and are generally well tolerated. However, at this time, no data have been published concerning the development of severe rhinorrhea with a great impact on quality of life in patients treated with alpha-1-adrenergic antagonists. We report two men with BPH treated with two different alpha-adrenergic antagonists; alfuzosin and doxazocin. The naranjo quality scale documented a probable adverse drug reaction (score 7) between rhinorrhea and treatmenr with alpha-1-adrenergic antagonists. In conclusion we reported that alpha-1-adrenergic antagonists are able to induce rhinorrhea in patients with BPH.

Keywords: Benign prostatic hyperplasia (BPH), lower urinary tract symptoms (LUTS).

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2014
Page: [159 - 160]
Pages: 2
DOI: 10.2174/1574886309666140527112408
Price: $58

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