Effect of Botanicals on Inflammation and Skin Aging: Analyzing the Evidence
Amanda Suggs, Patricia Oyetakin-White and Elma D. Baron
Affiliation: Department of Dermatology, University Hospitals Case Medical Center 11100 Euclid Avenue, Lakeside 3500, Mailstop 5028, Cleveland, OH 44106-5028, USA.
The skin and its immune system manifest a decline in physiologic function as it undergoes aging. External
insults such as ultraviolet light exposure cause inflammation, which may enhance skin aging even further leading to
cancer and signs of photoaging. There is a potential role for botanicals as an adjunct modality in the prevention of skin
aging. Numerous over-the-counter anti-aging products are commercially available, many of which boast unverified claims
to reduce stress, inflammation and correct signs of aging. In this article we reviewed the scientific literature for data on
frequently published “anti-inflammaging” additives such as vitamins A, C and E and green tea. We also analyzed the
evidence available on five promising ingredients commonly found in anti-aging products, namely, argan oil, rosemary,
pomegranate, Coenzyme Q10, and Coffeeberry. Though there may be an increasing amount of scientific data on a few of
these novel botanicals, in general, there remains a lack of clinical data to support the anti-aging claims made.
Keywords: Argan oil, coenzyme Q10, coffeeberry, green tea, pomegranate extract, rosemary extract, vitamin A, vitamin C.
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