Endocrine, Metabolic & Immune Disorders - Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Emilio Jirillo  
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico
Bari
Italy

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Characterization of the Immune Inflammatory Profile in Obese Asthmatic Children

Author(s): Thea Magrone, Maria Simone, Luigi Mappa, Riccardina Tesse, Paola Giordano, Maria Altamura, Irene Munno.

Abstract:

Asthma and obesity are two common disorders often associated in children and characterized by an inflammatory status. Growing evidences support a connection between obesity and asthma since weight reduction can improve asthmatic symptoms.

In this study, we have enrolled eighty children: 17 non asthmatics and non obese, 19 obese, 28 asthmatics-obese and, 16 asthmatics non-obese, respectively. In all participants, respiratory functional tests and body mass index (BMI) were calculated. Moreover, systemic inflammation of biomarkers such as T helper (h)1-type, Th2-type and T regulatory-type serum cytokines along with major adipokines was determined.

Data will show that the association between asthma and obesity leads to a predominant Th1-type response with an increase in pro-inflammatory cytokines. This inflammatory profile in asthmatics-obese children is sustained by elevated serum levels of leptin and visfatin, while adiponectin concentration is rather diminished.

Finally, levels of systemic inflammatory biomarkers positively correlate with the increase in BMI values in all population subgroups.

Keywords: Adiponectin, adipose tissue, asthma, children, cytokine, leptin, obesity, resistin, visfatin.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2014
Page: [187 - 195]
Pages: 9
DOI: 10.2174/1871530314666140526095211
Price: $58