Post-stroke depression is an important psychological consequence of ischemic stroke, and affects around one
third of stroke patients at any time post-stroke. It has a negative impact on patient morbidity and mortality, and as such
development of effective post-stroke recognition and treatment strategies are very important. There are several therapeutic
strategies for post-stroke depression, including both pharmacological and non-pharmacological approaches. In this review,
we present evidence regarding the underlying biology of post-stroke depression, commonalities between post-stroke
depression and Major Depressive Disorder and explore several treatment approaches, including antidepressant therapy,
psychotherapy, surgical therapy, electroconvulsive therapy, acupuncture, music therapy and natural products. Further
experimental and clinical studies are required, particularly in emerging fields such as the role of nutraceuticals in the
treatment of stroke.
Acupuncture, antidepressant, nutraceutical, post-stroke depression, psychotherapy, stroke.
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, P.O. Box 19395-5487.