The intricate relationship between stress and skin conditions has been documented since ancient times. Recent
clinical observations also link psychological stress to the onset or aggravation of multiple skin diseases. However, the
exact underlying mechanisms have only been studied and partially revealed in the past 20 years or so. In this review, the
authors will discuss the recent discoveries in the field of “Brain-Skin Connection”, summarizing findings from the
overlapping fields of psychology, endocrinology, skin neurobiology, skin inflammation, immunology, and pharmacology.