Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Bioactivities of Novel 1,3,4-oxadiazole Derivatives Containing Pyridine Moiety

Author(s): Guo-Xiang Sun, Yan-Xia Shi, Zhao-Hui Sun, Ming-Yan Yang, Hong-Ke Wu, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li, Yong-Gang Zhang.

Graphical Abstract:


Abstract:

In this paper, some novel 1,3,4-oxadiazole derivatives containing 4-pyridyl group were synthesized under microwave assistant condition by multi-step reactions. The structures were characterized by 1H NMR, MS and elemental analyses. The target compounds were evaluated for their fungicidal activities, and the results indicated that some of the title compounds displayed good antifungal activities.

Keywords: 1, 3, 4-oxadiazole, antifungal activity, microwave synthesis, pyridine.

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Article Details

VOLUME: 11
ISSUE: 9
Year: 2014
Page: [1119 - 1123]
Pages: 5
DOI: 10.2174/1570180811666140522002929
Price: $58