From the Table to the Bedside: Can Food-Derived Sulforaphane be used as a Novel Agent to Treat Leukemia?
Koramit Suppipat and H. Daniel Lacorazza
Affiliation: 1102 Bates Street, FC83.20, Houston, Texas 77030, USA.
Keywords: Animal model, cancer, clinical trial, leukemia, natural product, sulforaphane, therapy.
The extensive use of the same chemotherapeutics over several decades has resulted in a growing incidence of
chemoresistant cancer cells and secondary malignancies. Therefore, there is an increasing need for new drugs to treat
high-risk cancer patients with a higher selectivity for cancer cells and lower toxicity to normal cells. Sulforaphane is
released upon hydrolysis of glucoraphanin, a constituent of cruciferous vegetables, by myrosinases that are present in the
plant or intestinal microbes. Despite a large number of studies describing the chemopreventive and chemotherapeutic
properties of sulforaphane in solid tumors, there is little information on the properties of sulforaphane in hematological
malignancies. In this review, we discuss the anti-carcinogenic properties of sulforaphane, the need of higher doses than
dietary intake, and the challenges related to testing sulforaphane as an adjunctive agent in combination with the current
standard of care for frontline blood cancer.
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