Quercetin, a natural protective bioflavonoid, possesses diverse pharmacologic effects, such as antioxidant, anti-inflammatory,
anti-proliferative, and anti-angiogenic activities. Recently, quercetin’s effect in cancer prevention and treatment was recognized.
However, the poor water solubility and low-bioavailability of quercetin limit its clinical use in cancer therapy. Nanotechnology provides
a method to create novel formulations for hydrophobic drug. Nanoparticles-delivered quercetin has attracted many attentions for its
enhanced anticancer potential and promising clinical application. This review will discuss the application of nanotechnology in quercetin
delivery for cancer therapy.