From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol
Xuan Yang, Xun Li and Jinyu Ren
Affiliation: The Second Department of General Surgery, the First Hospital of Lanzhou University, Donggang West Rd No.1, Lanzhou, 730000, Gansu, China.
Resveratrol (3, 5, 4’-trihydroxy-trans-stilbene, RVT), a stilbenoid, polyphenol phytochemical present in berries, grape, peanuts
and wine. It has been suggested as a major contributor to “French Paradox” that reduces the mortality from coronary heart disease (CHD)
by consuming RVT in red wine even in some of French population with a high-fat intake. With extensive research, it has been found that
RVT is a versatile and pleiotropic agent, it not only possesses cardiovascular-protective benefits by its powerful antioxidant capacity,
anti-inflammatory, regulating metabolism and anti-aging effects, but also has strong anti-tumor activities through inhibiting tumor cell
proliferation, inducing cell apoptosis, promoting tumor cell differentiation, preventing tumor invasion and metastasis, and further
moderating the host immune system to kill tumor cells. This review will focus on RVT’s anti-tumor activity and tumor prevention
potential including: the anti-tumor spectrum in vitro and in vivo; molecular targets and signal pathways involving RVT anti-tumor
mechanisms; evidences from clinical trial for its bioavailability, dosage, toxicity and benefit in humans; and its prospective including its
analog, deviations, and combinative chemotherapy.
Keywords: Anti-cancer activity, cancer therapy, mechanisms, paradox, resveratrol.
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