Garlic-Derived Allyl Sulfides in Cancer Therapy
Hai-Xia Cao, Ke-Xiang Zhu, Jian-Gao Fan and Liang Qiao
Affiliation: Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of medicine, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China.
Keywords: Allyl sulfides, apoptosis, carcinogenesis, cell cycle, Garlic, organosulfur compounds.
Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits
of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic
derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to
summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms
responsible for the anti-carcinogenesis effects of garlic and its derivatives.
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