Current Neurovascular Research

Prof. Kenneth Maiese
Neurology and Neurosciences UMDNJ
205 South Orange Avenue, F1220
Newark, NJ 07101
USA
Email: wntin75@yahoo.com

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Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

Author(s): Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu Krishnamurthy

Affiliation: Associate Professor & Head, School of Biotechnology, Coordinator, DBT - Centre for Bioinformatics, National Institute of Technology Calicut, Calicut - 673601, India.

Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.

Abstract:

Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.

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Article Details

VOLUME: 11
ISSUE: 3
Page: [271 - 278]
Pages: 8
DOI: 10.2174/1567202611666140520151002