Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death
Rajanikant Golgodu Krishnamurthy.
Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and
survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and
pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this
protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current
knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.
Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.
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