Microglial Activation with Reduction in Autophagy Limits White Matter Lesions and Improves Cognitive Defects During Cerebral Hypoperfusion
Zhao Yang, Nan Zhang, Hanchao Shen, Chuangan Lin, Li Lin and Bangqing Yuan
Affiliation: Department of Neurosurgery, The 476th Hospital of PLA, Fuzhou, Fujian 350025, China.
Keywords: Autophagy, cerebral, cognitive deficits, hypoperfusion, microglia, white matter lesions.
Microglial activation plays a vital role in the pathogenesis of white matter lesions (WMLs) during chronic
cerebral hypo perfusion. Autophagy has been associated with both microglia survival and cell death. Yet, the role of
autophagy during microglial activation in chronic cerebral ischemia is still unknown. We used a chronic cerebral
hypoperfusion model by permanent stenosis of bilateral common carotid artery in mice to study microglial activation and
autophagy. However, the autophagy inhibitor (3-methyladenine) could attenuate microglial autophagic activation,
decrease white matter lesions, and improve working memory during chronic cerebral hypoperfusion in mice. In
conclusion, chronic cerebral hypoperfusion that leads to microglial activation and autophagy induction exacerbates white
matter lesions and cognitive deficits in mice. Our findings represent a potential novel target for chronic cerebral
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