Lung Cancer Chemotherapy, New Treatment and Related Patents
Attapon Cheepsattayakorn and Ruangrong Cheepsattayakorn
Affiliation: 10th Zonal Tuberculosis and Chest Disease Center, 143 Sridornchai Road, Changklan Muang, Chiang Mai 50100, Thailand and 10th Office of Disease Prevention and Control, 447 Lumphun Road, Watgate Muang, Chiang Mai 50,000, Thailand.
Keywords: Cancer, chemotherapy, lung, lung cancer-molecular alterations, related patents, treatment.
The majority of patients with lung cancer present with advanced stage which contributes to death of more people
than any other malignancy in the world. The discovery of a number of lung cancer-molecular alterations contributes to
uniquely targeted therapies with specific inhibitors for non-small cell lung cancer such as erlotinib, gefitinib and crizotinib.
Pemetrexed has statistically shown significantly reduced adverse side effects of drug compared with docetaxel.
V1801, an analog of gefitinib may overcome gefitinib resistance in patients with non-small cell lung cancer. Thymosin
α1, an immunomodulator significantly improves patient’s quality of life by enhancing T-cell function, stimulation of Tcell
maturation and differentiation. Various novel compounds and chemotherapeutics were introduced in 2013 patents
such as taxane, quinazoline, arylamino purine, benzodiazepine, pyrrolopyrimidine, nitrobenzamide, cyclopropane amide,
4-iodo-3-nitrobenzamide, heteroaryl (alkyl) dithiocarbamate, and histone deacetylase in treating non-small-cell lung cancer
and piperidine, piperazine, picoplatin, and arsenic trioxide in treating small-cell lung cancer.
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