Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG


Atrial Fibrillation and Chronic Kidney Disease in Hypertension: A Common and Dangerous Triad

Author(s): Dimitris Tsiachris, Costas Tsioufis, Patrizio Mazzone, Niki Katsiki and Christodoulos Stefanadis

Affiliation: 3 Kolokotroni Street, 15236, P. Penteli, Athens, Greece.

Graphical Abstract:


Hypertension (HTN) and chronic kidney disease (CKD) often coexist sharing common pathophysiological factors that both in combination and separately induce fibrotic changes in the heart provoking atrial fibrillation (AF). AF, per se, is associated with a 4- to 5-fold increased risk of stroke and a 2-fold increased risk of all-cause death. The co-existence of AF with HTN and renal dysfunction considerably increases morbidity and mortality. Management of AF in hypertensive patients with CKD is complex and multidisciplinary, since these patients have both a prothrombotic state and a coagulopathy with an increased tendency for bleeding. Novel oral anticoagulants such as dabigatran, rivaroxaban and apixaban offer better efficacy and safety especially in patients without optimal treatment with vitamin K antagonists.

Keywords: Atrial fibrillation, anticoagulants, chronic kidney disease, hypertension.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [111 - 120]
Pages: 10
DOI: 10.2174/1570161112666140519154615