Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Synthesis and Antimicrobial Activities of (4,5,6,7-Tetrahydro-1H-indazol- 2(3H)-yl)thiazole Derivatives

Author(s): Krzysztof Z. Laczkowski, Konrad Misiura, Anna Biernasiuk and Anna Malm

Affiliation: Department of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.

Keywords: Antibacterial drugs, Antifungal drugs, Candida spp, Tetrahydroindazole, Thiazole.

Graphical Abstract:


Abstract:

Synthesis, characterization and investigation of antimicrobial activities of ten novel tetrahydroindazolylthiazoles is presented. Their structures were determined using 1H and 13C NMR, FAB(+)-MS and HRMS analyses. Among the derivatives, compound 3f shows strong antibacterial activity against S. aureus ATCC 43300, S. aureus ATCC 25923, and S. epidermidis ATCC 12228 with MIC 7.81 µg/ml, and good activity against S. aureus ATCC 6538 with MIC 31.25 µg/ml. Compounds 3a-e and 3j show good antifungal activity with MIC values ranging from 31.25 µg/ml to 250 µg/ml.

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Article Details

VOLUME: 11
ISSUE: 8
Page: [960 - 967]
Pages: 8
DOI: 10.2174/1570180811666140516233913