Synthesis and Antimicrobial Activities of (4,5,6,7-Tetrahydro-1H-indazol- 2(3H)-yl)thiazole Derivatives
Krzysztof Z. Laczkowski, Konrad Misiura, Anna Biernasiuk and Anna Malm
Affiliation: Department of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.
Keywords: Antibacterial drugs, Antifungal drugs, Candida spp, Tetrahydroindazole, Thiazole.
Synthesis, characterization and investigation of antimicrobial activities of ten novel tetrahydroindazolylthiazoles
is presented. Their structures were determined using 1H and 13C NMR, FAB(+)-MS and HRMS analyses.
Among the derivatives, compound 3f shows strong antibacterial activity against S. aureus ATCC 43300, S. aureus ATCC
25923, and S. epidermidis ATCC 12228 with MIC 7.81 µg/ml, and good activity against S. aureus ATCC 6538 with MIC
31.25 µg/ml. Compounds 3a-e and 3j show good antifungal activity with MIC values ranging from 31.25 µg/ml to 250
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