Using Current Data to Define New Approach in Age Related Macular Degeneration: Need to Accelerate Translational Research
Akshay Anand, Kaushal Sharma, Wei Chen and Neel Kamal Sharma
Affiliation: Neuroscience Research Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Age related macular degeneration (AMD) is one of the major retinal degenerative disease of ageing whose
complex genetic basis remains undeciphered. The involvement of various other factors like mitochondrial genes, cytoskeletal
proteins and the role of epigenetics has been described in this review. Several population based AMD genetic
studies have been carried out worldwide. Despite the increased publication of reports, clinical translation still eludes this
davastating disease. We suggest models to address roadblocks in clinical translation hoping that these would be beneficial
to drive AMD research towards innovative biomarkers and therapeutics Therefore, addressing the need large autopsy
studies and combining it with efficient use of bioinformatic tools, statistical modeling and probing SNP-biomarker association
are key to time bound resolution of this disease.
Keywords: Age related macular degeneration, Mitochondrial genes, Epigenetics, SNP, Biomarkers, Translational research,
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