Cardiovascular & Hematological Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Debabrata Mukherjee
Department of Internal Medicine
Texas Tech University
El Paso,TX


Improvement of Apolipoprotein B in Argentine Indigenous School Children after Vitamin D Supplementation

Author(s): Valeria Hirschler, Gustavo Maccallini, Milva Sanchez, Gonzalez Claudio, Claudia Molinari, on behalf of San Antonio de los Cobres Study Group Collaborators Graciela Colque, Marcelo Figueroa, Claudio Arnada, Mariana Hidalgo.

Graphical Abstract:


Objective: To determine whether vitamin D supplementation improves non-traditional cardiovascular risk factors such as Apo B levels among indigenous children.

Methods: A prospective two-year study evaluated a treated cohort of 190 children (104 males) aged 9.4+ 2.2 years. Children were divided into group A (n=104; 54.7%) and group B (n=86; 45.3%). Both groups received vitamin D supplementation with 100,000 u/year; group B was treated in 2013 and group A in 2014. All subjects were evaluated at the end of each treatment and anthropometric measures, lipids and vitamin D levels between the two groups were compared.

Results: Changes in vitamin D levels were significantly higher in Group A, which was supplied in 2014, than in group B, which was not supplied in 2014 (6.8 vs 0.96 ng/dL; respectively). Levels of LDL-C and Apo B were improved in group A versus B: LDL-C (-5.7 vs 6.9 mg/dL respectively) and Apo B (-0.9 vs 11. mg/dL respectively). Several multiple regression linear analyses showed that changes in vitamin D were significantly associated with lower LDL-C levels (Beta- 0.41, p<0.01; R2 0.07); and with lower Apo B levels (Beta-0.37, p<0.01; R2 0.17).

Conclusion: Vitamin D supplementation among indigenous children could improve Apo B levels.

Keywords: Apo B levels, indigenous children, vitamin D supplementation, cardiovascular risk, indigenous, children, apolipoprotein.

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Article Details

Year: 2015
Page: [137 - 145]
Pages: 9
DOI: 10.2174/1871525712666140516102319
Price: $58