Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University


A Comprehensive View on Metabolic Pathway Analysis Methodologies

Author(s): Namrata Tomar and Rajat K. De

Affiliation: Machine Intelligence Unit, Indian Statistical Institute, 203 Barrackpore Trunk Road, Kolkata 700108, India.


Advances in ‘omics’ high-throughput technologies have led to a vast amount and quality of available biological data. It has fostered the development of bioinformatics methods to interpret these data. In this regard, characterization of cellular metabolism is a useful task to understand the phenotypic capabilities of an organism. Several in silico approaches have emerged for analysis of metabolic pathways, including structural and stoichiometric analysis, metabolic flux analysis, metabolic control analysis, and several kinetic modeling based analysis. The present article provides the comprehensive survey on existing metabolic pathway analysis methodologies.

Keywords: Elementary flux mode analysis, extreme pathway analysis, flux balance analysis, metabolic pathway modeling.

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Article Details

Page: [295 - 305]
Pages: 11
DOI: 10.2174/1574893609666140516005147
Price: $58